HIV-1 and TB co-infection skew the SARS-CoV-2 T cell response
SARS-CoV-2-specific CD4 T cell attributes, rather than magnitude, associate with disease severity, with severe disease being characterized by poor polyfunctional potential, reduced proliferation capacity and enhanced HLA-DR expression.
The Wellcome Centre for Infectious Diseases Research in Africa fosters investigator-led approaches via the overarching scientific objective of combatting infection, especially HIV-1 and tuberculosis, through clinical and laboratory research.
A recent study from the University of Cape Town (UCT) confirmed that people living with diabetes (PLWD) are at an increased risk of severe COVID‑19 (hospitalisation and mortality). The findings were published in the journal Diabetes Research and Clinical Practice.
Increased IL-17A network connectivity serves as an indicator of elevated systemic inflammation and immune activation induced by advanced HIV infection, and predicts mortality in patients with HIV-tuberculosis co-infection.
No classes, tutorials, laboratory work or tests will take place on Monday, 19 April or Tuesday, 20 April. For safety reasons, campus will be locked down and no one, other than emergency services, will be allowed access.