HIV-1 and TB co-infection skew the SARS-CoV-2 T cell response
SARS-CoV-2-specific CD4 T cell attributes, rather than magnitude, associate with disease severity, with severe disease being characterized by poor polyfunctional potential, reduced proliferation capacity and enhanced HLA-DR expression.
Image of scientist holding up a Petri dish
Supporting Excellence
The Wellcome Centre for Infectious Diseases Research in Africa fosters investigator-led approaches via the overarching scientific objective of combatting infection, especially HIV-1 and tuberculosis, through clinical and laboratory research.
Macrophages infected with M. tuberculosis; image by Dr Suraj Parihar
Basic Science
Our Basic Science Platform provides the laboratory infrastructure and technical support to ensure the safe handling of infectious material.
Subgraph of the ANIMA network for dataset HIVsetB
Biomedical Data Integration
We work with multidimensional clinical and scientific data at the molecular, cellular, clinical and population levels.
Image of a researcher and study participant reading an informed consent document
Clinical Research
CIDRI-Africa supports clinical studies in the community at our facility at Site B in Khayelitsha.


Saturday, 24 July 2021
People with diabetes at risk of severe COVID-19, study confirms

A recent study from the University of Cape Town (UCT) confirmed that people living with diabetes (PLWD) are at an increased risk of severe COVID‑19 (hospitalisation and mortality). The findings were published in the journal Diabetes Research and Clinical Practice.

Publication Date:
Tue, 20 Jul 2021 - 09:00
Investigating the dynamic inflammatory profile of tuberculosis patients with and without HIV-1 co-infection

Increased IL-17A network connectivity serves as an indicator of elevated systemic inflammation and immune activation induced by advanced HIV infection, and predicts mortality in patients with HIV-tuberculosis co-infection.

Publication Date:
Mon, 24 May 2021 - 08:30
Fire affecting the Rondebosch campus of the University of Cape Town (UCT)

No classes, tutorials, laboratory work or tests will take place on Monday, 19 April or Tuesday, 20 April. For safety reasons, campus will be locked down and no one, other than emergency services, will be allowed access.

Publication Date:
Mon, 19 Apr 2021 - 12:00
CIDRI-Africa enrolls first patient in the MESA-TB study

The phase 2 study will evaluate the safety and immunogenicity of the M72/AS01E TB vaccine in people living with HIV.

Publication Date:
Wed, 14 Apr 2021 - 11:45