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HIV-1 and TB co-infection skew the SARS-CoV-2 T cell response
SARS-CoV-2-specific CD4 T cell attributes, rather than magnitude, associate with disease severity, with severe disease being characterized by poor polyfunctional potential, reduced proliferation capacity and enhanced HLA-DR expression.
Image of scientist holding up a Petri dish
Supporting Excellence
The Wellcome Centre for Infectious Diseases Research in Africa fosters investigator-led approaches via the overarching scientific objective of combatting infection, especially HIV-1 and tuberculosis, through clinical and laboratory research.
Macrophages infected with M. tuberculosis; image by Dr Suraj Parihar
Basic Science
Our Basic Science Platform provides the laboratory infrastructure and technical support to ensure the safe handling of infectious material.
Subgraph of the ANIMA network for dataset HIVsetB
Biomedical Data Integration
We work with multidimensional clinical and scientific data at the molecular, cellular, clinical and population levels.
Image of a researcher and study participant reading an informed consent document
Clinical Research
CIDRI-Africa supports clinical studies in the community at our facility at Site B in Khayelitsha.

News

Saturday, 15 May 2021
In remembrance: Viwe Mgudlwa

It is with deep sadness that we write to share with you the news of the death of our colleague Ms Viwe Mgudlwa on Thursday, 24 December 2020. Ms Mgudlwa was in Engcobo, Eastern Cape, at the time of her sudden death.

Publication Date:
Mon, 11 Jan 2021 - 09:00
Using bacterial shape to understand TB gene function

In order to better understand individual gene function, and to help predict the mechanisms of action of certain tuberculosis (TB) drugs, a team of researchers at the Institute of Infectious Disease and Molecular Medicine (IDM) in the University of Cape Town’s (UCT) Faculty of Health Sciences studied the various factors that can impact the cell shape of Mycobacterium tuberculosis (M. tb), which causes TB. The paper was recently published in eLife.

Publication Date:
Tue, 08 Dec 2020 - 09:15
Super Resolution image of CD4 clusters at the surface of a lymphocyte (cyan), and bound HIV particles (Immunolabelled HIV p17, magenta [SR] and yellow [Diffraction-limited TIRF]) Credit: Caron Jacobs
Democratizing Imaging for Infectious Disease Research in Africa: Chan Zuckerberg Initiative award for UCT postdoc

Dr Caron Jacobs has been awarded support by the Chan Zuckerberg Initiative Imaging Scientists programme. The programme promotes synthesis of biological and technological expertise, and advancement of imaging tools.

Publication Date:
Thu, 03 Dec 2020 - 10:00
UCT boasts three new African Academy of Sciences fellows

The African Academy of Sciences (AAS) has nominated three University of Cape Town (UCT) academics as 2019 fellows. The fellowships are awarded to scholars who have achieved academic excellence and have contributed to significant scientific advancements in their fields of study.

Publication Date:
Tue, 20 Oct 2020 - 14:00

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