HIV-1 and TB co-infection skew the SARS-CoV-2 T cell response
SARS-CoV-2-specific CD4 T cell attributes, rather than magnitude, associate with disease severity, with severe disease being characterized by poor polyfunctional potential, reduced proliferation capacity and enhanced HLA-DR expression.
The Wellcome Centre for Infectious Diseases Research in Africa fosters investigator-led approaches via the overarching scientific objective of combatting infection, especially HIV-1 and tuberculosis, through clinical and laboratory research.
It is with deep sadness that we write to share with you the news of the death of our colleague Ms Viwe Mgudlwa on Thursday, 24 December 2020. Ms Mgudlwa was in Engcobo, Eastern Cape, at the time of her sudden death.
In order to better understand individual gene function, and to help predict the mechanisms of action of certain tuberculosis (TB) drugs, a team of researchers at the Institute of Infectious Disease and Molecular Medicine (IDM) in the University of Cape Town’s (UCT) Faculty of Health Sciences studied the various factors that can impact the cell shape of Mycobacterium tuberculosis (M. tb), which causes TB. The paper was recently published in eLife.
Dr Caron Jacobs has been awarded support by the Chan Zuckerberg Initiative Imaging Scientists programme. The programme promotes synthesis of biological and technological expertise, and advancement of imaging tools.