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Free PMC Publications by CIDRI Fellows

Free PMC Publications by CIDRI Fellows

Emmanuel Chigutsa 2009 to 2012

Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Newly Diagnosed Pulmonary TB Patients in Tanzania.
Denti P, Jeremiah K, Chigutsa E, Faurholt-Jepsen D, PrayGod G, Range N, Castel S, Wiesner L, Hagen CM, Christiansen M, Changalucha J, McIlleron H, Friis H, Andersen AB.
PLoS One. 2015 Oct 26;10(10):e0141002. PMID: 26501782 PMCID: PMC4621059

Impact of nonlinear interactions of pharmacokinetics and MICs on sputum bacillary kill rates as a marker of sterilizing effect in tuberculosis.
Chigutsa E, Pasipanodya JG, Visser ME, van Helden PD, Smith PJ, Sirgel FA, Gumbo T, McIlleron H.
Antimicrob Agents Chemother. 2015 Jan;59(1):38-45. PMID: 25313213 PMCID: PMC4291375

The pyrazinamide susceptibility breakpoint above which combination therapy fails.
Gumbo T, Chigutsa E, Pasipanodya J, Visser M, van Helden PD, Sirgel FA, McIlleron H.
J Antimicrob Chemother. 2014 May 12. PMID: 24821594 PMCID: PMC4130380

Nutritional Supplementation Increases Rifampin Exposure among Tuberculosis Patients Coinfected with HIV.
Jeremiah K, Denti P, Chigutsa E, Faurholt-Jepsen D, PrayGod G, Range N, Castel S, Wiesner L, Hagen CM, Christiansen M, Changalucha J, McIlleron H, Friis H, Andersen AB.
Antimicrob Agents Chemother. 2014 Jun;58(6):3468-3474. PMID: 24709267 PMCID: PMC4068463

Moxifloxacin population pharmacokinetics and model-based comparison of efficacy between moxifloxacin and ofloxacin in African patients.
Zvada SP, Denti P, Sirgel FA, Chigutsa E, Hatherill M, Charalambous S, Mungofa S, Wiesner L, Simonsson US, Jindani A, Harrison T, McIlleron HM.
Antimicrob Agents Chemother. 2014 Jan;58(1):503-10. PMID: 24189253 PMCID: PMC3910772

Pharmacometrics: opportunity for reducing disease burden in the developing world: the case of Africa.
Pillai G, Davies G, Denti P, Steimer JL, McIlleron H, Zvada S, Chigutsa E, Ngaimisi E, Mirza F, Tadmor B, Holford NH.
CPT Pharmacometrics Syst Pharmacol. 2013 Aug 28;2 PMID: 23985967 PMCID: PMC3828009

A time-to-event pharmacodynamic model describing treatment response in patients with pulmonary tuberculosis using days to positivity in automated liquid mycobacterial culture.
Chigutsa E, Patel K, Denti P, Visser M, Maartens G, Kirkpatrick CM, McIlleron H, Karlsson MO.
Antimicrob Agents Chemother. 2013 Feb;57(2):789-95. PMID: 23183433 PMCID: PMC3553722

Population Pharmacokinetics and Pharmacodynamics of Ofloxacin in South African Patients With Multi-Drug Resistant Tuberculosis.
Chigutsa E, Meredith S, Wiesner L, Padayatchi N, Harding J, Moodley P, Mac Kenzie WR, Weiner M, McIlleron H, Kirkpatrick CM.
Antimicrob Agents Chemother. 2012 May 7. PMID: 22564839 PMCID: PMC3393408

The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications.
Chigutsa E, Visser ME, Swart EC, Denti P, Pushpakom S, Egan D, Holford NH, Smith PJ, Maartens G, Owen A, McIlleron H.
Antimicrob Agents Chemother. 2011 Sep;55(9):4122-7. PMID: 21709081 PMCID: PMC3165308

 

Rabecca Tadokera 2009 to 2011

Cytotoxic mediators in paradoxical HIV-tuberculosis immune reconstitution inflammatory syndrome.
Wilkinson KA, Walker NF, Meintjes G, Deffur A, Nicol MP, Skolimowska KH, Matthews K, Tadokera R, Seldon R, Maartens G, Rangaka MX, Besra GS, Wilkinson RJ.
J Immunol. 2015 Feb 15;194(4):1748-54. PMID: 25589068 PMCID: PMC4319311

Matrix metalloproteinases and tissue damage in HIV-tuberculosis immune reconstitution inflammatory syndrome.
Tadokera R, Meintjes GA, Wilkinson KA, Skolimowska KH, Walker N, Friedland JS, Maartens G, Elkington PT, Wilkinson RJ.
Eur J Immunol. 2014 Jan;44(1):127-36.PMID: 24136296 PMCID: PMC3992843

Role of the interleukin 10 family of cytokines in patients with immune reconstitution inflammatory syndrome associated with HIV infection and tuberculosis.
Tadokera R, Wilkinson KA, Meintjes GA, Skolimowska KH, Matthews K, Seldon R, Rangaka MX, Maartens G, Wilkinson RJ.
J Infect Dis. 2013 Apr;207(7):1148-56. PMID: 23303806 PMCID: PMC3583273

Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome.
Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Tadokera R, Conesa-Botella A, Seldon R, Rangaka MX, Rebe K, Pepper DJ, Morroni C, Colebunders R, Maartens G, Wilkinson RJ.
Am J Respir Crit Care Med. 2012 Aug 15;186(4):369-77. PMID: 22700860 PMCID: PMC3443811

Hypercytokinaemia accompanies HIV-tuberculosis immune reconstitution inflammatory syndrome.
Tadokera R, Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Seldon R, Chegou NN,             Maartens G, Rangaka MX, Rebe K, Walzl G, Wilkinson RJ.
Eur Respir J. 2010 Sep 3. PMID: 20817712 PMCID: PMC3242045

 

Alexander Zawaira 2010 to 2011

1.Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.
Chopera DR, Cotton LA, Zawaira A, Mann JK, Ngandu NK, Ntale R, Carlson JM, Mlisana K, Woodman Z, de Assis Rosa D, Martin E, Miura T, Pereyra F, Walker BD, Gray CM, Martin DP, Ndung'u T, Brockman MA, Karim SA, Brumme ZL, Williamson C; CAPRISA 002 Study Team.
J Virol. 2012 Dec;86(24):13423-33. PMID: 23015721 PMCID:PMC3503133

 

Suzana Savvi 2009 to 2011

IL-4Rα-dependent alternative activation of macrophages is not decisive for Mycobacterium tuberculosis pathology and bacterial burden in mice.
Guler R, Parihar SP, Savvi S, Logan E, Schwegmann A, Roy S, Nieuwenhuizen NE, Ozturk M, Schmeier S, Suzuki H, Brombacher F.
PLoS One. 2015 Mar 19;10(3):e0121070. PMID: 25790379 PMCID: PMC4366092

Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening.
Abrahams GL, Kumar A, Savvi S, Hung AW, Wen S, Abell C, Barry CE 3rd, Sherman DR, Boshoff HI, Mizrahi V.
Chem Biol. 2012 Jul 27;19(7):844-54. PMID: 22840772 PMCID: PMC3421836

Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids.
Savvi S, Warner DF, Kana BD, McKinney JD, Mizrahi V, Dawes SS.
J Bacteriol. 2008 Jun;190(11):3886-95. PMID: 18375549 PMCID: PMC2395058

 

Motasim Badri 2010 to 2013

Performance of serum C-reactive protein as a screening test for smear-negative tuberculosis in an ambulatory high HIV prevalence population.
Wilson D, Badri M, Maartens G.
PLoS One. 2011 Jan 10;6(1):e15248. PMID: 21249220 PMCID: PMC3018418

Lack of association between stavudine exposure and lipoatrophy, dysglycaemia, hyperlactataemia and hypertriglyceridaemia: a prospective cross sectional study.
Sinxadi PZ, van der Walt JS, McIlleron HM, Badri M, Smith PJ, Dave JA, Levitt NS, Maartens G.
AIDS Res Ther. 2010 Jul 14;7:23. PMID: 20630064 PMCID: PMC2914641

Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples.
Dheda K, Davids V, Lenders L, Roberts T, Meldau R, Ling D, Brunet L, van Zyl Smit R, Peter J, Green C, Badri M, Sechi L, Sharma S, Hoelscher M, Dawson R, Whitelaw A, Blackburn J, Pai M, Zumla A.
PLoS One. 2010 Mar 24;5(3):e9848. PMID: 20352098 PMCID: PMC2844421

Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis.
Pooran A, Booth H, Miller RF, Scott G, Badri M, Huggett JF, Rook G, Zumla A, Dheda K.
BMC Pulm Med. 2010 Feb 22;10:7. PMID: 20170555 PMCID: PMC2837635

The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study.
Shaboodien G, Engel ME, Syed FF, Poulton J, Badri M, Mayosi BM.
BMC Med Genet. 2009 Apr 27;10:37. PMID: 19397801 PMCID: PMC2679724

Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting.
Dheda K, Van-Zyl Smit RN, Sechi LA, Badri M, Meldau R, Symons G, Khalfey H, Carr I, Maredza A, Dawson R, Wainright H, Whitelaw A, Bateman ED, Zumla A.
PLoS One. 2009;4(3):e4689. PMID: 19277111 PMCID: PMC2650091

Utility of CD4 cell counts for early prediction of virological failure during antiretroviral therapy in a resource-limited setting.
Badri M, Lawn SD, Wood R.
BMC Infect Dis. 2008 Jul 4;8:89.PMID: 18601727 PMCID: PMC2459184

 

Alfred Bere 2009 to 2011

Effect of Female Genital Schistosomiasis and Anti-Schistosomal Treatment on Monocytes, CD4+ T-Cells and CCR5 Expression in the Female Genital Tract.
Kleppa E, Ramsuran V, Zulu S, Karlsen GH, Bere A, Passmore JA, Ndhlovu P, Lillebø K, Holmen SD, Onsrud M, Gundersen SG, Taylor M, Kjetland EF, Ndung'u T.
PLoS One. 2014 Jun 4;9(6):e98593. PMID: 24896815 PMCID: PMC4045760

Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study.
McKinnon LR, Hughes SM, De Rosa SC, Martinson JA, Plants J, Brady KE, Gumbi PP, Adams DJ, Vojtech L, Galloway CG, Fialkow M, Lentz G, Gao D, Shu Z, Nyanga B, Izulla P, Kimani J, Kimwaki S, Bere A, Moodie Z, Landay AL, Passmore JA, Kaul R, Novak RM, McElrath MJ,
Hladik F.
PLoS One. 2014 Jan 15;9 (1) PMID:24454917 PMCID: PMC3893217

HIV-specific T-cell responses detected in the genital tract of chronically HIV-infected women are largely monofunctional.
Bere A, Denny L, Naicker P, Burgers WA, Passmore JA.
Immunology. 2013 Jul;139(3):342-51. PMID: 23374084 PMCID: PMC3701181

Polyclonal expansion of cervical cytobrush-derived T cells to investigate HIV-specific responses in the female genital tract.
Bere A, Denny L, Burgers WA, Passmore JA.
Immunology. 2010 May;130(1):23-33. PMID: 20201983 PMCID: PMC2855790

Comparison of polyclonal expansion methods to improve the recovery of cervical cytobrush-derived T cells from the female genital tract of HIV-infected women.
Bere A, Denny L, Hanekom W, Burgers WA, Passmore JA.
J Immunol Methods. 2010 Mar 31;354(1-2):68-79. PMID: 20149794 PMCID: PMC2854893

Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infection.
Gumbi PP, Nkwanyana NN, Bere A, Burgers WA, Gray CM, Williamson AL, Hoffman M, Coetzee D, Denny L, Passmore JA.
J Virol. 2008 Sep;82(17):8529-36. PMID: 18562528 PMCID: PMC2519691

 

Nobubelo Ngandu 2009 to 2011

Early initiation of antiretroviral therapy amongst young children: a long way to go.
Doherty T, Ngandu N, Blume J, Leon N, Mathews C.
J Acquir Immune Defic Syndr. 2015 Apr 13. PMID: 25886929 PMCID: PMC4577609

Evidence of pervasive biologically functional secondary structures within the genomes of eukaryotic single-stranded DNA viruses.
Muhire BM, Golden M, Murrell B, Lefeuvre P, Lett JM, Gray A, Poon AY, Ngandu NK, Semegni Y, Tanov EP, Monjane AL, Harkins GW, Varsani A, Shepherd DN, Martin DP.
J Virol. 2014 Feb;88(4):1972-89. PMID: 24284329 PMCID:PMC3911531

Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models.
Lacerda M, Moore PL, Ngandu NK, Seaman M, Gray ES, Murrell B, Krishnamoorthy M, Nonyane M, Madiga M, Wibmer CK, Sheward D, Bailer RT, Gao H, Greene KM, Karim SS, Mascola JR, Korber BT, Montefiori DC, Morris L, Williamson C, Seoighe C; CAVD-NSDP Consortium.
Virol J. 2013 Dec 2;10:347. PMID: 24295501 PMCID: PMC4220805

Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design.
Ping LH, Joseph SB, Anderson JA, Abrahams MR, Salazar-Gonzalez JF, Kincer LP, Treurnicht FK, Arney L, Ojeda S, Zhang M, Keys J, Potter EL, Chu H, Moore P, Salazar MG, Iyer S, Jabara C, Kirchherr J, Mapanje C, Ngandu N, Seoighe C, Hoffman I, Gao F, Tang Y, Labranche C, Lee B, Saville A, Vermeulen M, Fiscus S, Morris L, Karim SA, Haynes BF, Shaw GM, Korber BT, Hahn BH, Cohen MS, Montefiori D, Williamson C, Swanstrom R; CAPRISA Acute Infection Study and the Center for HIV-AIDS Vaccine Immunology Consortium.
J Virol. 2013 Jul;87(13):7218-33. PMID: 23616655 PMCID: PMC3700278

Rapid, complex adaptation of transmitted HIV-1 full-length genomes in subtype C-infected individuals with differing disease progression.
Abrahams MR, Treurnicht FK, Ngandu NK, Goodier SA, Marais JC, Bredell H, Thebus R, de Assis Rosa D, Mlisana K, Seoighe C, Karim SA, Gray CM, Williamson C.
AIDS. 2013 Feb 20;27(4):507-18. Erratum in: AIDS. 2013 Jun 1;27(9):1525.
PMID: 23370465 PMCID: PMC3720865

Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape.
Moore PL, Gray ES, Wibmer CK, Bhiman JN, Nonyane M, Sheward DJ, Hermanus T, Bajimaya S, Tumba NL, Abrahams MR, Lambson BE, Ranchobe N, Ping L, Ngandu N, Abdool Karim Q, Abdool Karim SS, Swanstrom RI, Seaman MS, Williamson C, Morris L.
Nat Med. 2012 Nov;18(11):1688-92. PMID: 23086475 PMCID: PMC3494733

Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.
Chopera DR, Cotton LA, Zawaira A, Mann JK, Ngandu NK, Ntale R, Carlson JM, Mlisana K, Woodman Z, de Assis Rosa D, Martin E, Miura T, Pereyra F, Walker BD, Gray CM, Martin DP, Ndung'u T, Brockman MA, Karim SA, Brumme ZL, Williamson C; CAPRISA 002 Study Team.
J Virol. 2012 Dec;86(24):13423-33. PMID: 23015721 PMCID: PMC3503133

Temporal association of HLA-B*81:01- and HLA-B*39:10-mediated HIV-1 p24 sequence evolution with disease progression.
Ntale RS, Chopera DR, Ngandu NK, Assis de Rosa D, Zembe L, Gamieldien H, Mlotshwa M, Werner L, Woodman Z, Mlisana K, Abdool Karim S, Gray CM, Williamson C; CAPRISA 002 Study Team.
J Virol. 2012 Nov;86(22):12013-24. PMID: 22933291 PMCID: PMC3486481

Evidence of HIV-1 adaptation to host HLA alleles following chimp-to-human transmission.
Ngandu NK, Seoighe C, Scheffler K.
Virol J. 2009 Oct 10;6:164. PMID: 19818146 PMCID: PMC2765438

Human immunodeficiency virus-specific gamma interferon enzyme-linked immunospot assay responses targeting specific regions of the proteome during primary subtype C infection are poor predictors of the course of viremia and set point.
Gray CM, Mlotshwa M, Riou C, Mathebula T, de Assis Rosa D, Mashishi T, Seoighe C,
Ngandu N, van Loggerenberg F, Morris L, Mlisana K, Williamson C, Karim SA; CAPRISA 002 Acute Infection Study Team.
J Virol. 2009 Jan;83(1):470-8. PMID: 18945774 PMCID: PMC2612312

 

Phumla Sinxadi 2010 to 2013

Pharmacogenetics of plasma efavirenz exposure in HIV-infected adults and children in South Africa.
Sinxadi PZ, Leger PD, McIlleron HM, Smith PJ, Dave JA, Levitt NS, Maartens G, Haas DW.
Br J Clin Pharmacol. 2015 Jul;80(1):146-56. PMID: 25611810 PMCID: PMC4500334

Effects of rifampin-based antituberculosis therapy on plasma efavirenz concentrations in children vary by CYP2B6 genotype.
McIlleron HM, Schomaker M, Ren Y, Sinxadi P, Nuttall JJ, Gous H, Moultrie H, Eley B, Merry C, Smith P, Haas DW, Maartens G.
AIDS. 2013 Jul 31;27(12):1933-40. PMID: 24180002 PMCID: PMC3879806

Mitochondrial genomics and antiretroviral therapy-associated metabolic complications in HIV-infected Black South Africans: a pilot study.
Sinxadi PZ, Dave JA, Samuels DC, Heckmann JM, Maartens G, Levitt NS, Wester CW, Haas DW, Hulgan T.
AIDS Res Hum Retroviruses. 2013 Jul;29(7):1031-9. PMID: 23428049 PMCID: PMC3685683

Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study.
Sinxadi PZ, McIlleron HM, Dave JA, Smith PJ, Levitt NS, Maartens G.
AIDS Res Ther. 2012 Oct 26;9(1):32. PMID: 23098156 PMCID: PMC3533776

Pharmacogenomics of HIV therapy: summary of a workshop sponsored by the National Institute of Allergy and Infectious Diseases.
Haas DW, Kuritzkes DR, Ritchie MD, Amur S, Gage BF, Maartens G, Masys D, Fellay J, Phillips E, Ribaudo HJ, Freedberg KA, Petropoulos C, Manolio TA, Gulick RM, Haubrich R, Kim P, Dehlinger M, Abebe R, Telenti A;
Workshop Pharmacogenomics-A Path Towards Personalized HIV Care. PMID: 22180526
PMCID: PMC3533776

Lack of association between stavudine exposure and lipoatrophy, dysglycaemia, hyperlactataemia and hypertriglyceridaemia: a prospective cross sectional study.
Sinxadi PZ, van der Walt JS, McIlleron HM, Badri M, Smith PJ, Dave JA, Levitt NS, Maartens G.
AIDS Res Ther. 2010 Jul 14;7:23. PMID: 20630064 PMCID: PMC2914641

 

Rory Leisegang 2010 to 2012

Short term adherence tool predicts failure on second line protease inhibitor-based antiretroviral therapy: an observational cohort study.
Court R, Leisegang R, Stewart A, Sunpath H, Murphy R, Winternheimer P, Ally M, Maartens G.
BMC Infect Dis. 2014 Dec 4;14:664. PMID: 25472544 PMCID: PMC4266950

A novel Markov model projecting costs and outcomes of providing antiretroviral therapy to public patients in private practices versus public clinics in South Africa.
Leisegang R, Maartens G, Hislop M, Sargent J, Darkoh E, Cleary S.
PLoS One. 2013;8(2):e53570. PMID: 23405073 PMCID: PMC3566152

Factors influencing retention in care after starting antiretroviral therapy in a rural South African programme.
Boyles TH, Wilkinson LS, Leisegang R, Maartens G.
PLoS One. 2011 May 3;6(5):e19201. PMID: 21559280 PMCID: PMC3086905

Improving the evidence base of Markov models used to estimate the costs of scaling up antiretroviral programmes in resource-limited settings.
Leisegang R, Maartens G, Hislop M, Regensberg L, Cleary S.
BMC Health Serv Res. 2010 Jul 2;10 Suppl 1:S3. PMID: 20594369 PMCID: PMC2895747

Early and late direct costs in a Southern African antiretroviral treatment programme: a retrospective cohort analysis.
Leisegang R, Cleary S, Hislop M, Davidse A, Regensberg L, Little F, Maartens G.
PLoS Med. 2009 Dec;6(12):e1000189. PMID: 19956658 PMCID: PMC2777319

 

Charles Wiysonge 2010 to 2011

Knowledge and practices relating to malaria in a semi-urban area of Cameroon: choices and sources of antimalarials, self-treatment and resistance.
Nsagha DS, Njunda AL, Kamga HL, Nsagha SM, Nguedia Assob JC, Wiysonge CS, Tabah EN, Njamnshi AK.
Pan Afr Med J. 2011;9:8. PMID: 22145055 PMCID: PMC3215530

'Communicate to vaccinate' (COMMVAC). building evidence for improving communication about childhood vaccinations in low- and middle-income countries: protocol for a programme of research.
Lewin S, Hill S, Abdullahi LH, de Castro Freire SB, Bosch-Capblanch X,Glenton C, Hussey GD, Jones CM,Kaufman J,Lin V,Mahomed H, Rhoda L, Robinson P, Waggie Z, Willis N, Wiysonge CS.
Implement Sci. 2011 Dec 2;6:125. PMID: 22132930 PMCID: PMC3259054

The African Vaccine-Preventable Diseases Network: a vaccine advocacy initiative.
Wiysonge CS,Armah GE,Madhi SA,Were F,Kitaka SB,Akoua-Koffi C,Gresenguet G, Gatheru Z, Maranga PW, Dicko A, Falade AG, Boula AY, Kuit SB, Odusanya OO, Sow PS, Lakhani N, Mpabalwani EM, Tamfum JJ, Hussey GD.
Pan Afr Med J. 2011;8:24. PMID: 22121433 PMCID: PMC3201589

An introduction to systematic reviews and meta-analysis: a workshop report on promoting evidence based medical practice through capacity building in research synthesis.
Mbuagbaw L, Wiysonge CS, Nsagha DS, Ongolo-Zogo P, Pantoja T.
Pan Afr Med J. 2011;8:15. PMID: 22121424 PMCID: PMC3221401

Evidence summaries tailored to health policy-makers in low- and middle-income countries.
Rosenbaum SE, Glenton C, Wiysonge CS, Abalos E, Mignini L, Young T, Althabe F, Ciapponi A, Marti SG, Meng Q, Wang J, la Hoz Bradford AM, Kiwanuka SN, Rutebemberwa E, Pariyo GW, Flottorp S, Oxman AD.
Bull World Health Organ. 2011 Jan 1;89(1):54-61. PMID: 21346891 PMCID: PMC3040014

Improving communication for immunisation in Africa: contribution of the Vaccines for Africa website.
Wiysonge CS, Waggie Z, Rhoda L, Hussey G.
Pan Afr Med J. 2009 Apr 14;2:3. PMID: 21119955 PMCID: PMC2984270

 

Olivia Carulei 2010 to 2013

Six host-range restricted poxviruses from three genera induce distinct gene expression profiles in an in vivo mouse model.
Offerman K, Deffur A, Carulei O, Wilkinson R, Douglass N, Williamson AL.
BMC Genomics. 2015 Jul 8;16:510. PMID: 26153454 PMCID: PMC4495948

The complete genome sequences of poxviruses isolated from a penguin and a pigeon in South Africa and comparison to other sequenced avipoxviruses.
Offerman K, Carulei O, van der Walt AP, Douglass N, Williamson AL.
BMC Genomics. 2014 Jun 12;15(1):463. PMID: 24919868 PMCID: PMC4229897

Phylogenetic and histological variation in avipoxviruses isolated in South Africa.
Offerman K, Carulei O, Gous TA, Douglass N, Williamson AL.
J Gen Virol. 2013 Oct;94(Pt 10):2338-51. PMID: 23860490 PMCID: PMC3785031

Phylogenetic analysis of three genes of Penguinpox virus corresponding to Vaccinia virus G8R (VLTF-1), A3L (P4b) and H3L reveals that it is most closely related to Turkeypox virus, Ostrichpox virus and Pigeonpox virus.
Carulei O, Douglass N, Williamson AL.
Virol J. 2009 May 8;6:52. PMID: 19426497 PMCID: PMC2688499

 

Liesl J Zühlke 2010 to 2012

An open-access, mobile compatible, electronic patient register for rheumatic heart disease ('eRegister') based on the World Heart Federation's framework for patient registers.
van Dam J, Musuku J, Zühlke LJ, Engel ME, Nestle N, Tadmor B, Spector J, Mayosi BM.
Cardiovasc J Afr. 2015 Oct 6;26:1-7. PMID: 26444995 PMCID: PMC4780020

Effect of distance to health facility on the maintenance of INR therapeutic ranges in rheumatic heart disease patients from Cape Town: no evidence for an association.
Barth DD, Zühlke LJ, Joachim A, Hoegger T, Mayosi BM, Engel ME.
BMC Health Serv Res. 2015 Jun 5;15:219. PMID: 26041470 PMCID: PMC4456049

Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart Disease Registry (the REMEDY study).
Zühlke L, Engel ME, Karthikeyan G, Rangarajan S, Mackie P, Cupido B, Mauff K, Islam S, Joachim A, Daniels R, Francis V, Ogendo S, Gitura B, Mondo C, Okello E, Lwabi P, Al-Kebsi MM, Hugo-Hamman C, Sheta SS, Haileamlak A, Daniel W, Goshu DY, Abdissa SG, Desta AG, Shasho BA, Begna DM, ElSayed A, Ibrahim AS, Musuku J, Bode-Thomas F, Okeahialam BN, Ige O, Sutton C, Misra R, Abul Fadl A, Kennedy N, Damasceno A, Sani M, Ogah OS, Olunuga T, Elhassan HH, Mocumbi AO, Adeoye AM, Mntla P, Ojji D, Mucumbitsi J, Teo K, Yusuf S, Mayosi BM.
Eur Heart J. 2015 May 7;36(18):1115-22a. PMID: 25425448 PMCID: PMC4422972

The case for global investment in rheumatic heart-disease control.
Wyber R, Zühlke L, Carapetis J.
Bull World Health Organ. 2014 Oct 1;92(10):768-70. PMID: 25378731 PMCID: PMC4208481

Spectrum of cardiac disease in maternity in a low-resource cohort in South Africa.
Sliwa K, Libhaber E, Elliott C, Momberg Z, Osman A, Zühlke L, Lachmann T, Nicholson L, Thienemann F, Roos-Hesselink J, Anthony J.
Heart. 2014 Dec;100(24):1967-74. PMID: 25227705 PMCID: PMC4251204

Incidence, prevalence and outcomes of rheumatic heart disease in South Africa: a systematic review protocol.
Zühlke L, Watkins D, Engel ME.
BMJ Open. 2014 Jun 10;4(6):e004844. PMID: 24916089 PMCID: PMC4067809

Congenital heart disease and rheumatic heart disease in Africa: recent advances and current priorities.
Zühlke L, Mirabel M, Marijon E.
Heart. 2013 Nov;99(21):1554-61. Review. PMID: 23680886 PMCID: PMC3812860

The promise of computer-assisted auscultation in screening for structural heart disease and clinical teaching.
Zühlke L, Myer L, Mayosi BM.
Cardiovasc J Afr. 2012 Feb 23;23:1-4. PMID: 22358127 PMCID: PMC3721800

Letter to the Editor:
Zühlke LJ, Engel M.
Clin Epidemiol. 2011;3:171-2. PMID: 21750626 PMCID: PMC3130902

Global research priorities in rheumatic fever and rheumatic heart disease.
Carapetis JR, Zühlke LJ.
Ann Pediatr Cardiol. 2011 Jan;4(1):4-12. PMID: 21677798 PMCID: PMC3104531

 

Lena Andersen 2011

A pilot study of a nurse-delivered cognitive behavioral therapy intervention (Ziphamandla) for adherence and depression in HIV in South Africa.
Andersen LS, Magidson JF, O'Cleirigh C, Remmert JE, Kagee A, Leaver M, Stein DJ, Safren SA, Joska J.
J Health Psychol. 2016 Apr 26. PMID: 27121977 ? PMCID

 

Keren Middelkoop 2011 to 2012

Reply to Yates et al.
Middelkoop K, Mathema B, Whitelaw A, Bekker LG, Wood R.
J Infect Dis. 2015 May 1;211(9):1510-1. PMID: 25387580 PMCID: PMC4392870

Transmission of tuberculosis in a South African community with a high prevalence of HIV infection.
Middelkoop K, Mathema B, Myer L, Shashkina E, Whitelaw A, Kaplan G, Kreiswirth B, Wood R, Bekker LG.
J Infect Dis. 2015 Jan 1;211(1):53-61. PMID: 25053739 PMCID: PMC4334823

The impact of ART on TB case fatality stratified by CD4 count for HIV-positive TB patients in Cape Town, South Africa (2009-2011).
Kaplan R, Caldwell J, Middelkoop K, Bekker LG, Wood R.
J Acquir Immune Defic Syndr. 2014 May 12. PMID: 24820105 PMCID: PMC4161924

Decreasing household contribution to TB transmission with age: a retrospective geographic analysis of young people in a South African township.
Middelkoop K, Bekker LG, Morrow C, Lee N, Wood R.
BMC Infect Dis. 2014 Apr 23;14(1):221. PMID: 24758715 PMCID: PMC4012060

Factors affecting tuberculosis strain success over 10 years in a high TB- and HIV-burdened community.
Middelkoop K, Bekker LG, Mathema B, Myer L, Shashkina E, Whitelaw A, Kurepina N, Kaplan G, Kreiswirth B, Wood R.
Int J Epidemiol. 2014 Mar 7. PMID: 24609068 PMCID: PMC4121554

Indoor social networks in a South African township: potential contribution of location to tuberculosis transmission.
Wood R, Racow K, Bekker LG, Morrow C, Middelkoop K, Mark D, Lawn SD.
PLoS One. 2012;7(6):e39246. PMID: 22768066 PMCID: PMC3387133

Projecting the benefits of antiretroviral therapy for HIV prevention: the impact of population mobility and linkage to care.
Andrews JR, Wood R, Bekker LG, Middelkoop K, Walensky RP.
J Infect Dis. 2012 Aug 15;206(4):543-51. PMID: 22711905 PMCID: PMC3491737

Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria.
Wood R, Racow K, Bekker LG, Middelkoop K, Vogt M, Kreiswirth BN, Lawn SD.
BMC Infect Dis. 2012 Feb 27;12:47. PMID: 22369353 PMCID: PMC3349560

Antiretroviral treatment cohort analysis using time-updated CD4 counts: assessment of bias with different analytic methods.
Kranzer K, Lewis JJ, White RG, Glynn JR, Lawn SD, Middelkoop K, Bekker LG, Wood R.
PLoS One. 2011;6(11):e27763. PMID: 22114687 PMCID: PMC3219676

Social mixing patterns within a South African township community: implications for respiratory disease transmission and control.
Johnstone-Robertson SP, Mark D, Morrow C, Middelkoop K, Chiswell M, Aquino LD, Bekker LG, Wood R.
Am J Epidemiol. 2011 Dec 1;174(11):1246-55. PMID: 22071585 PMCID: PMC3224253

Burden of new and recurrent tuberculosis in a major South African city stratified by age and HIV-status.
Wood R, Lawn SD, Caldwell J, Kaplan R, Middelkoop K, Bekker LG.
PLoS One. 2011;6(10):e25098. PMID: 22016763 PMCID: PMC3189963

High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa.
Kranzer K, van Schaik N, Karmue U, Middelkoop K, Sebastian E, Lawn SD, Wood R, Bekker LG.
PLoS One. 2011;6(9):e25244. PMID: 21969875PMCID: PMC3182182

Sexual health, HIV risk, and retention in an adolescent HIV-prevention trial preparatory cohort.
Jaspan HB, Flisher AJ, Myer L, Mathews C, Middelkoop K, Mark D, Bekker LG.
J Adolesc Health. 2011 Jul;49(1):42-6. PMID: 21700155 PMCID: PMC3124666

Force of tuberculosis infection among adolescents in a high HIV and TB prevalence community:  a cross-sectional observation study.
Middelkoop K, Bekker LG, Liang H, Aquino LD, Sebastian E, Myer L, Wood R.
BMC Infect Dis. 2011 Jun 1;11:156. PMID: 21631918 PMCID: PMC3130671

Antiretroviral Therapy and TB Notification Rates in a High HIV Prevalence South African Community.
Middelkoop K, Bekker LG, Myer L, Johnson LF, Kloos M, Morrow C, Wood R.
J Acquir Immune Defic Syndr. 2011 Mar 1;56(3):263-269. PMID: 21317585
PMCID: PMC3801097

Tuberculosis transmission to young children in a South African community: modeling household and community infection risks.
Wood R, Johnstone-Robertson S, Uys P, Hargrove J, Middelkoop K, Lawn SD, Bekker LG.
Clin Infect Dis. 2010 Aug 15;51(4):401-8. PMID: 20604716 PMCID: PMC3101801

Antiretroviral program associated with reduction in untreated prevalent tuberculosis in a South African township.
Middelkoop K, Bekker LG, Myer L, Whitelaw A, Grant A, Kaplan G, McIntyre J, Wood R.
Am J Respir Crit Care Med. 2010 Oct 15;182(8):1080-5. PMID: 20558626 PMCID: PMC2970849

A qualitative assessment of perspectives on the inclusion of adolescents in HIV vaccine trials in South Africa.
Jaspan HB, Soka NF, Mathews C, Flisher AJ, Mark D, Middelkoop K, Wood R, Bekker LG.
Int J STD AIDS. 2010 Mar;21(3):172-6. PMID: 20215620 PMCID: PMC3878910

Changing prevalence of tuberculosis infection with increasing age in high-burden townships in South Africa.
Wood R, Liang H, Wu H, Middelkoop K, Oni T, Rangaka MX, Wilkinson RJ, Bekker LG, Lawn SD.
Int J Tuberc Lung Dis. 2010 Apr;14(4):406-12. PMID: 20202297 PMCID: PMC2837545

Childhood tuberculosis infection and disease: a spatial and temporal transmission analysis in a South African township.
Middelkoop K, Bekker LG, Morrow C, Zwane E, Wood R.
S Afr Med J. 2009 Oct;99(10):738-43. PMID: 20128273 PMCID: PMC2932468

Molecular epidemiology of Mycobacterium tuberculosis in a South African community with high HIV prevalence.
Middelkoop K, Bekker LG, Mathema B, Shashkina E, Kurepina N, Whitelaw A, Fallows D, Morrow C, Kreiswirth B, Kaplan G, Wood R.
J Infect Dis. 2009 Oct 15;200(8):1207-11. PMID: 19764885 PMCID: PMC2932637

Rates of tuberculosis transmission to children and adolescents in a community with a high prevalence of HIV infection among adults.
Middelkoop K, Bekker LG, Myer L, Dawson R, Wood R.
Clin Infect Dis. 2008 Aug 1;47(3):349-55. PMID: 18558885 PMCID: PMC3816246

 

Zizipho Z Mbulawa 2011 to 2012

Human papillomavirus prevalence in South African women and men according to age and human immunodeficiency virus status.
Mbulawa ZZ, Coetzee D, Williamson AL.
BMC Infect Dis. 2015 Oct 26;15:459. PMID: 26502723 PMCID: PMC4624185

Comprehensive profiling of the vaginal microbiome in HIV positive women using massive parallel semiconductor sequencing.
Ameur A, Meiring TL, Bunikis I, Häggqvist S, Lindau C, Lindberg JH, Gustavsson I, Mbulawa ZZ, Williamson AL, Gyllensten U.
Sci Rep. 2014 Mar 18;4:4398. PMID: 24637939 PMCID: PMC3957130

Increased alpha-9 human papillomavirus species viral load in human immunodeficiency virus positive women.
Mbulawa ZZ, Johnson LF, Marais DJ, Gustavsson I, Moodley JR, Coetzee D, Gyllensten U, Williamson AL.
BMC Infect Dis. 2014 Jan 31;14:51. PMID: 24484380 PMCID: PMC3922074

 

Adebayo Shittu 2011

An assessment on DNA microarray and sequence-based methods for the characterization of methicillin-susceptible Staphylococcus aureus from Nigeria.
Shittu AO, Oyedara O, Okon K, Raji A, Peters G, von Müller L, Schaumburg F, Herrmann M, Ruffing U.
Front Microbiol. 2015 Oct 20;6:1160. PMID: 26539185 PMCID: PMC4612102

Molecular epidemiology of Methicillin-resistant Staphylococcus aureus in Africa: a systematic review.
Abdulgader SM, Shittu AO, Nicol MP, Kaba M.
Front Microbiol. 2015 Apr 30;6:348. Review. PMID: 25983721 PMCID: PMC4415431

Characterization of methicillin-susceptible and -resistant staphylococci in the clinical setting: a multicentre study in Nigeria.
Shittu A, Oyedara O, Abegunrin F, Okon K, Raji A, Taiwo S, Ogunsola F, Onyedibe K, Elisha G.
BMC Infect Dis. 2012 Nov 2;12:286. PMID: 23121720 PMCID: PMC3529121

Antibiotic resistance and molecular epidemiology of Staphylococcus aureus in Nigeria.
Shittu AO, Okon K, Adesida S, Oyedara O, Witte W, Strommenger B, Layer F, Nübel U.
BMC Microbiol. 2011 May 5;11:92. PMID: 21545717 PMCID: PMC3112067

Cooccurrence of predominant Panton-Valentine leukocidin-positive sequence type (ST) 152 and multidrug-resistant ST 241 Staphylococcus aureus clones in Nigerian hospitals.
Okon KO, Basset P, Uba A, Lin J, Oyawoye B, Shittu AO, Blanc DS.
J Clin Microbiol. 2009 Sep;47(9):3000-3. PMID: 19605575 PMCID: PMC2738054

Phenotypic and molecular characterization of Staphylococcus aureus isolates expressing low- and high-level mupirocin resistance in Nigeria and South Africa.
Shittu AO, Udo EE, Lin J.
BMC Infect Dis. 2009 Jan 28;9:10. PMID: 19175912 PMCID: PMC2640400

 

Nonhlanhla Mkhize (nee Nkwanyana) 2011

South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication.
Richardson SI, Gray ES, Mkhize NN, Sheward DJ, Lambson BE, Wibmer CK, Masson L, Werner L, Garrett N, Passmore JA, Karim QA, Karim SS, Williamson C, Moore PL, Morris L.
Retrovirology. 2015 Jun 24;12:54. PMID: 26105197 PMCID: PMC4479312

CD4 T cell depletion at the cervix during HIV infection is associated with accumulation of terminally differentiated T cells.
Gumbi PP, Jaumdally SZ, Salkinder AL, Burgers WA, Mkhize NN, Hanekom W, Coetzee D, Williamson A, Passmore JS.
J Virol. 2011 Dec;85(24):13333-41. PMID: 21994461 PMCID: PMC3233181

Stability and transport of cervical cytobrushes for isolation of mononuclear cells from the female genital tract.
Liebenberg LJ, Gamieldien H, Mkhize NN, Jaumdally SZ, Gumbi PP, Denny L, Passmore JA.
J Immunol Methods. 2011 Feb 12. PMID: 21324321 PMCID: PMC3081068

Persistence of genital tract T cell responses in HIV-infected women on highly active antiretroviral therapy.
Mkhize NN, Gumbi PP, Liebenberg LJ, Ren Y, Smith P, Denny L, Passmore JA.
J Virol. 2010 Oct;84(20):10765-72. PMID: 20686039 PMCID: PMC2950605

Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tract.
Nkwanyana NN, Gumbi PP, Roberts L, Denny L, Hanekom W, Soares A, Allan B, Williamson AL, Coetzee D, Olivier AJ, Burgers WA, Passmore JA.
Immunology. 2009 Sep;128(1 Suppl):e746-57. PMID: 19740336 PMCID: PMC2753906

Impact of mucosal inflammation on cervical human immunodeficiency virus (HIV-1)-specific CD8 T-cell responses in the female genital tract during chronic HIV infection.
Gumbi PP, Nkwanyana NN, Bere A, Burgers WA, Gray CM, Williamson AL, Hoffman M,
Coetzee D, Denny L, Passmore JA.
J Virol. 2008 Sep;82(17):8529-36. PMID: 18562528 PMCID: PMC2519691

 

Tiroyaone Brombacher (nee Bogale) 2010 to 2011

Nippostrongylus-induced intestinal hypercontractility requires IL-4 receptor alpha-responsiveness by T cells in mice.
Schmidt S, Hoving JC, Horsnell WG, Mearns H, Cutler AJ, Brombacher TM, Brombacher F.
PLoS One. 2012;7(12):e52211. PMID: 23284939 PMCID: PMC3527412

 

Abraham Olivier 2011 to 2012

Distinct Cytokine Patterns in Semen Influence Local HIV Shedding and HIV Target Cell Activation.
Olivier AJ, Masson L, Ronacher K, Walzl G, Coetzee D, Lewis DA, Williamson AL, Passmore JA, Burgers WA.
J Infect Dis. 2014 Jan 2. PMID: 24273175 PMCID:PMC3969547

Impact of human immunodeficiency virus 1 infection and inflammation on the composition and yield of cervical mononuclear cells in the female genital tract.
Nkwanyana NN, Gumbi PP, Roberts L, Denny L, Hanekom W, Soares A, Allan B, Williamson AL,             Coetzee D, Olivier AJ, Burgers WA, Passmore JA. Abstract
Immunology. 2009 Sep;128(1 Suppl):e746-57.  PMID: 19740336 PMCID: PMC2753906

 

Johan van der Watt 2010 to 2011

Plasma cytokine profiles in HIV-1 infected patients developing neuropathic symptoms shortly after commencing antiretroviral therapy: a case-control study.
Van der Watt JJ, Wilkinson KA, Wilkinson RJ, Heckmann JM.
BMC Infect Dis. 2014 Feb 10;14(1):71. PMID: 24512313 PMCID: PMC3928502

 

Reggie Mutetwa 2010 to 2013

Suboptimal specificity of Xpert MTB/RIF among treatment-experienced patients.
Metcalfe JZ, Makumbirofa S, Makamure B, Mutetwa R, Peñaloza RA, Sandy C, Bara W, Mungofa S, Hopewell PC, Mason P.
Eur Respir J. 2015 May;45(5):1504-6. PMID: 25792637 PMCID: PMC4948946

Impact of Xpert MTB/RIF on Antiretroviral Therapy-Associated Tuberculosis and Mortality: A Pragmatic Randomized Controlled Trial.
Mupfumi L, Makamure B, Chirehwa M, Sagonda T, Zinyowera S, Mason P, Metcalfe JZ, Mutetwa R.
Open Forum Infect Dis. 2014 Jun 25;1(1):ofu038. PMID: 25734106 PMCID: PMC4324195

Development of sample clean up methods for the analysis of Mycobacterium tuberculosis methyl mycocerosate biomarkers in sputum extracts by gas chromatography-mass spectrometry.
Nicoara SC, Turner NW, Minnikin DE, Lee OY, O'Sullivan DM, McNerney R, Mutetwa R, Corbett LE, Morgan GH.
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 1;986-987:135-42. PMID: 25728371
PMCID: PMC4381843

Prevalence of Extensively Drug Resistant Tuberculosis among Archived Multidrug Resistant Tuberculosis Isolates in Zimbabwe.
Sagonda T, Mupfumi L, Manzou R, Makamure B, Tshabalala M, Gwanzura L, Mason P, Mutetwa R.
Tuberc Res Treat. 2014;2014:349141. PMID: 24967101 PMCID: PMC4054961

Microscopic-observation drug-susceptibility assay for the diagnosis of drug-resistant tuberculosis in Harare, Zimbabwe.
Makamure B, Mhaka J, Makumbirofa S, Mutetwa R, Mupfumi L, Mason P, Metcalfe JZ.
PLoS One. 2013;8(2):e55872. PMID: 23409072 PMCID: PMC3569460

Detection of Mycobacterium tuberculosis in sputum by gas chromatography-mass                              spectrometry of methyl mycocerosates released by thermochemolysis.
O'Sullivan DM, Nicoara SC, Mutetwa R, Mungofa S, Lee OY, Minnikin DE, Bardwell MW,                  Corbett EL, McNerney R, Morgan GH.
PLoS One. 2012;7(3):e32836. PMID: 22403716 PMCID: PMC3293907

Diagnostic accuracy of commercial urinary lipoarabinomannan detection in African             tuberculosis suspects and patients.
Mutetwa R, Boehme C, Dimairo M, Bandason T, Munyati SS, Mangwanya D, Mungofa S, Butterworth AE, Mason PR, Corbett EL.
Int J Tuberc Lung Dis. 2009 Oct;13(10):1253-9. PMID: 19793430 PMCID: PMC3373957

 

Denis Chopera 2012

Magnitude and Kinetics of CD8(+) T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.
Ndhlovu ZM, Kamya P, Mewalal N, Kløverpris HN, Nkosi T, Pretorius K, Laher F, Ogunshola F, Chopera D, Shekhar K, Ghebremichael M, Ismail N, Moodley A, Malik A, Leslie A, Goulder PJ, Buus S, Chakraborty A, Dong K, Ndung'u T, Walker BD.
Immunity. 2015 Sep 15;43(3):591-604. PMID: 26362266 PMCID: PMC4575777

Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses.
Hancock G, Yang H, Yorke E, Wainwright E, Bourne V, Frisbee A, Payne TL, Berrong M, Ferrari G, Chopera D, Hanke T, Mothe B, Brander C, McElrath MJ, McMichael A, Goonetilleke N, Tomaras GD, Frahm N, Dorrell L.
PLoS Pathog. 2015 Feb 27;11(2):e1004658. PMID: 25723536 PMCID: PMC4344337

Early immune adaptation in HIV-1 revealed by population-level approaches.
Martin E, Carlson JM, Le AQ, Chopera DR, McGovern R, Rahman MA, Ng C, Jessen H, Kelleher AD, Markowitz M, Allen TM, Milloy MJ, Carrington M, Wainberg MA, Brumme ZL.
Retrovirology. 2014 Aug 29;11:64. PMID: 25212686 PMCID: PMC4190299

Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure.
Mann JK, Chopera D, Omarjee S, Kuang XT, Le AQ, Anmole G, Danroth R, Mwimanzi P, Reddy T, Carlson J, Radebe M, Goulder PJ, Walker BD, Abdool Karim S, Novitsky V, Williamson C, Brockman MA, Brumme ZL, Ndung'u T.
Virology. 2014 Nov;468-470:214-25. PMID: 25193656 PMCID: PMC4252354

Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.
Cotton LA, Kuang XT, Le AQ, Carlson JM, Chan B, Chopera DR, Brumme CJ, Markle TJ, Martin E, Shahid A, Anmole G, Mwimanzi P, Nassab P, Penney KA, Rahman MA, Milloy MJ, Schechter MT, Markowitz M, Carrington M, Walker BD, Wagner T, Buchbinder S, Fuchs J, Koblin B, Mayer KH, Harrigan PR, Brockman MA, Poon AF, Brumme ZL.
PLoS Genet. 2014 Apr 24;10(4):e1004295. PMID: 24762668 PMCID: PMC3998893

No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial.
Chopera DR, Mann JK, Mwimanzi P, Omarjee S, Kuang XT, Ndabambi N, Goodier S, Martin E, Naranbhai V, Karim SA, Karim QA, Brumme ZL, Ndung'u T, Williamson C, Brockman MA; CAPRISA 004 TRAPS Team.
PLoS One. 2013 Aug 28;8(8):e71758. PMID: 24015191 PMCID: PMC3756015

Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness.
Chopera DR, Cotton LA, Zawaira A, Mann JK, Ngandu NK, Ntale R, Carlson JM, Mlisana K, Woodman Z, de Assis Rosa D, Martin E, Miura T, Pereyra F, Walker BD, Gray CM, Martin DP, Ndung'u T, Brockman MA, Karim SA, Brumme ZL, Williamson C; CAPRISA 002 Study Team.
J Virol. 2012 Dec;86(24):13423-33. PMID: 23015721 PMCID: PMC3503133

Temporal association of HLA-B*81:01- and HLA-B*39:10-mediated HIV-1 p24 sequence evolution with disease progression.
Ntale RS, Chopera DR, Ngandu NK, Assis de Rosa D, Zembe L, Gamieldien H, Mlotshwa M, Werner L, Woodman Z, Mlisana K, Abdool Karim S, Gray CM, Williamson C; CAPRISA 002 Study Team.
J Virol. 2012 Nov;86(22):12013-24. PMID: 22933291 PMCID: PMC3486481

Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity.
Brockman MA, Chopera DR, Olvera A, Brumme CJ, Sela J, Markle TJ, Martin E, Carlson JM, Le AQ, McGovern R, Cheung PK, Kelleher AD, Jessen H, Markowitz M, Rosenberg E, Frahm N, Sanchez J, Mallal S, John M, Harrigan PR, Heckerman D, Brander C, Walker BD, Brumme ZL.
J Virol. 2012 Jun;86(12):6913-23. PMID: 22496233 PMCID: PMC3393549

 

Hlumani Ndlovu 2014 to 2016

Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4⁺ T cell responses.
Ndlovu H, Darby M, Froelich M, Horsnell W, Lühder F, Hünig T, Brombacher F.
PLoS Pathog. 2014 Feb 6;10(2):e1003906Feb. PMID: 24516382 PMCID: PMC3916406

IL-4Rα-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection.
Horsnell WG, Darby MG, Hoving JC, Nieuwenhuizen N, McSorley HJ, Ndlovu H, Bobat S, Kimberg M, Kirstein F, Cutler AJ, Dewals B, Cunningham AF, Brombacher F.
PLoS Pathog. 2013 Oct;9(10):e1003662. PMID: 24204255 PMCID: PMC3812011

 

Philippe Selhorst 2014 to 2016

M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding.
Selhorst P, Grupping K, Tong T, Crooks ET, Martin L, Vanham G, Binley JM, Ariën KK.
Retrovirology. 2013 Feb 1;10:12. PMID: 23375046 PMCID: PMC3571899

 

Lindi Masson 2014 to 2016

Restoration of CD4+ Responses to Copathogens in HIV-Infected Individuals on Antiretroviral Therapy Is Dependent on T Cell Memory Phenotype.
Riou C, Tanko RF, Soares AP, Masson L, Werner L, Garrett NJ, Samsunder N, Abdool Karim Q, Abdool Karim SS, Burgers WA.
J Immunol. 2015 Sep 1;195(5):2273-81. PMID: 26195814 PMCID: PMC4546876

South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication.
Richardson SI, Gray ES, Mkhize NN, Sheward DJ, Lambson BE, Wibmer CK, Masson L, Werner L, Garrett N, Passmore JA, Karim QA, Karim SS, Williamson C, Moore PL, Morris L.
Retrovirology. 2015 Jun 24;12:54. PMID: 26105197 PMCID: PMC4479312

Lower concentrations of chemotactic cytokines and soluble innate factors in the lower female genital tract associated with the use of injectable hormonal contraceptive.
Ngcapu S, Masson L, Sibeko S, Werner L, McKinnon LR, Mlisana K, Shey M, Samsunder N, Karim SA, Karim QA, Passmore JA.
J Reprod Immunol. 2015 Aug;110:14-21. PMID: 25956139 PMCID: PMC4779161

Genital inflammation and the risk of HIV acquisition in women.
Masson L, Passmore JA, Liebenberg LJ, Werner L, Baxter C, Arnold KB, Williamson C, Little F, Mansoor LE, Naranbhai V, Lauffenburger DA, Ronacher K, Walzl G, Garrett NJ, Williams BL, Couto-Rodriguez M, Hornig M, Lipkin WI, Grobler A, Abdool Karim Q, Abdool Karim SS.
Clin Infect Dis. 2015 Jul 15;61(2):260-9. PMID: 25900168 PMCID: PMC4565995

Distinct cytokine patterns in semen influence local HIV shedding and HIV target cell activation.
Olivier AJ, Masson L, Ronacher K, Walzl G, Coetzee D, Lewis DA, Williamson AL, Passmore JA, Burgers WA.
J Infect Dis. 2014 Apr 15;209(8):1174-84. PMID: 24273175 PMCID: PMC3969547

 

J Claire Hoving 2014 to 2016

The C-type lectin receptor CLECSF8/CLEC4D is a key component of anti-mycobacterial immunity.
Wilson GJ, Marakalala MJ, Hoving JC, van Laarhoven A, Drummond RA, Kerscher B, Keeton R, van de Vosse E, Ottenhoff TH, Plantinga TS, Alisjahbana B, Govender D, Besra GS, Netea MG, Reid DM, Willment JA, Jacobs M, Yamasaki S, van Crevel R, Brown GD.
Cell Host Microbe. 2015 Feb 11;17(2):252-9. PMID: 25674984 PMCID: PMC4334100

AIDS-related mycoses: the way forward.
Brown GD, Meintjes G, Kolls JK, Gray C, Horsnell W; Working Group from the EMBO-AIDS Related Mycoses Workshop, Achan B, Alber G, Aloisi M, Armstrong-James D, Beale M, Bicanic T, Black J, Bohjanen P, Botes A, Boulware DR, Brown G, Bunjun R, Carr W, Casadevall A, Chang C, Chivero E, Corcoran C, Cross A, Dawood H, Day J, De Bernardis F, De Jager V, De Repentigny L, Denning D, Eschke M, Finkelman M, Govender N, Gow N, Graham L, Gryschek R, Hammond-Aryee K, Harrison T, Heard N, Hill M, Hoving JC, Janoff E, Jarvis J, Kayuni S, King K, Kolls J, Kullberg BJ, Lalloo DG, Letang E, Levitz S, Limper A, Longley N, Machiridza TR, Mahabeer Y, Martinsons N, Meiring S, Meya D, Miller R, Molloy S, Morris L, Mukaremera L, Musubire AK, Muzoora C, Nair A, Nakiwala Kimbowa J, Netea M, Nielsen K, O'hern J, Okurut S, Parker A, Patterson T, Pennap G, Perfect J, Prinsloo C, Rhein J, Rolfes MA, Samuel C, Schutz C, Scriven J, Sebolai OM, Sojane K, Sriruttan C, Stead D, Steyn A, Thawer NK, Thienemann F, Von Hohenberg M, Vreulink JM, Wessels J, Wood K, Yang YL.
Trends Microbiol. 2014 Mar;22(3):107-9. PMID: 24581941 PMCID: PMC4129449

 

Tracy Meiring 2014 to 2016

Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia.
Adler DH, Wallace M, Bennie T, Abar B, Meiring TL, Williamson AL, Bekker LG.
Adv Virol. 2016;2016:7310894. PMID: 26997954 PMCID: PMC4779813

High risk human papillomavirus persistence among HIV-infected young women in South Africa.
Adler D, Wallace M, Bennie T, Abar B, Sadeghi R, Meiring T, Williamson AL, Bekker LG.
Int J Infect Dis. 2015 Apr;33:219-21. PMID: 25697074 PMCID: PMC4397173

Cervical dysplasia and high-risk human papillomavirus infections among HIV-infected and HIV-uninfected adolescent females in South Africa.
Adler DH, Wallace M, Bennie T, Mrubata M, Abar B, Meiring TL, Williamson AL, Bekker LG.
Infect Dis Obstet Gynecol. 2014;2014:498048. PMID: 25389377 PMCID: PMC4217359

Comprehensive profiling of the vaginal microbiome in HIV positive women using massive parallel semiconductor sequencing.
Ameur A, Meiring TL, Bunikis I, Häggqvist S, Lindau C, Lindberg JH, Gustavsson I, Mbulawa ZZ, Williamson AL, Gyllensten U.
Sci Rep. 2014 Mar 18;4:4398. PMID: 24637939 PMCID: PMC3957130

 

Tolullah Oni 2014 to 2016

Why the communicable/non-communicable disease dichotomy is problematic for public health control strategies: implications of multimorbidity for health systems in an era of health transition.
Oni T, Unwin N.
Int Health. 2015 Jun 23. PMID: 26103981 PMCID: PMC4638105

Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial.
Ndiaye BP, Thienemann F, Ota M, Landry BS, Camara M, Dièye S, Dieye TN, Esmail H, Goliath R, Huygen K, January V, Ndiaye I, Oni T, Raine M, Romano M, Satti I, Sutton S, Thiam A, Wilkinson KA, Mboup S, Wilkinson RJ, McShane H; MVA85A 030 trial investigators.
Lancet Respir Med. 2015 Mar;3(3):190-200. 26. PMID: 25726088 PMCID: PMC4648060

Patterns of HIV, TB, and non-communicable disease multi-morbidity in peri-urban South Africa- a cross sectional study.
Oni T, Youngblood E, Boulle A, McGrath N, Wilkinson RJ, Levitt NS.
BMC Infect Dis. 2015 Jan 17;15:20. PMID: 25595711 PMCID: PMC4300166

Prednisolone and Mycobacterium indicus pranii in tuberculous pericarditis.
Mayosi BM, Ntsekhe M, Bosch J, Pandie S, Jung H, Gumedze F, Pogue J, Thabane L, Smieja M, Francis V, Joldersma L, Thomas KM, Thomas B, Awotedu AA, Magula NP, Naidoo DP, Damasceno A, Chitsa Banda A, Brown B, Manga P, Kirenga B, Mondo C, Mntla P, Tsitsi JM, Peters F, Essop MR, Russell JB, Hakim J, Matenga J, Barasa AF, Sani MU, Olunuga T, Ogah O, Ansa V, Aje A, Danbauchi S, Ojji D, Yusuf S; IMPI Trial Investigators.
N Engl J Med. 2014 Sep 18;371(12):1121-30. PMID: 25178809 PMCID: PMC4912834

Chronic diseases and multi-morbidity--a conceptual modification to the WHO ICCC model for countries in health transition.
Oni T, McGrath N, BeLue R, Roderick P, Colagiuri S, May CR, Levitt NS.
BMC Public Health. 2014 Jun 9;14:575. PMID: 24912531 PMCID: PMC4071801

Diagnosis of childhood tuberculosis and host RNA expression in Africa.
Anderson ST, Kaforou M, Brent AJ, Wright VJ, Banwell CM, Chagaluka G, Crampin AC, Dockrell HM, French N, Hamilton MS, Hibberd ML, Kern F, Langford PR, Ling L, Mlotha R, Ottenhoff TH, Pienaar S, Pillay V, Scott JA, Twahir H, Wilkinson RJ, Coin LJ, Heyderman RS, Levin M, Eley B; ILULU Consortium; KIDS TB Study Group.
N Engl J Med. 2014 May 1;370(18):1712-23. PMID: 24785206 PMCID: PMC4069985

 

Suraj Parihar 2014 to 2016

Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice.
Parihar SP, Hartley MA, Hurdayal R, Guler R, Brombacher F.
Sci Rep. 2016 Sep 16;6:33458. PMID: 27632901 PMCID: PMC5025842

Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics.
Roy S, Schmeier S, Arner E, Alam T, Parihar SP, Ozturk M, Tamgue O, Kawaji H, de Hoon MJ, Itoh M, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Bajic VB, Guler R, Consortium F, Brombacher F, Suzuki H.
Nucleic Acids Res. 2015 Aug 18;43(14):6969-82. PMID: 26117544 PMCID: PMC4538831

IL-4Rα-dependent alternative activation of macrophages is not decisive for Mycobacterium tuberculosis pathology and bacterial burden in mice.
Guler R, Parihar SP, Savvi S, Logan E, Schwegmann A, Roy S, Nieuwenhuizen NE, Ozturk M, Schmeier S, Suzuki H, Brombacher F.
PLoS One. 2015 Mar 19;10(3):e0121070. PMID: 25790379 PMCID: PMC4366092

 

Natalie Strickland 2014 to 2016

Evaluating potential T-cell epitope peptides for detecting HIV-specific T cell responses in a highly diverse HIV-1 epidemic from Cameroon.
Tongo M, Riou C, Crunchant E, Müller TL, Strickland N, Mpoudi-Ngole E, Burgers WA.
AIDS. 2015 Mar 13;29(5):635-9. PMID: 25715106 PMCID: PMC4374151