Dr Parihar rated by the National Research Foundation

1 Mar 2018 - 11:45

Macrophages infected with Mycobacterium tuberculosisDr Suraj Parihar recently received a Y2 rating from the National Research Foundation. NRF rating is an international peer-review mechanism intended to recognise and encourage research of high quality and impact; the Y-rating is applied to promising researchers under the age of 40 who have held their doctorate for less than five years. Dr Parihar is investigating new avenues to combat tuberculosis (TB) within CIDRI-Africa’s Basic Science platform.

Mycobacterium tuberculosis is very well adapted to evade and exploit its hosts’ defensive systems1, and this is where Suraj’s interest lies—in host-pathogen interactions during infectious disease processes. Using mice as a model organism, he studies macrophage intrinsic killing functions against M. tuberculosis and Listeria monocytogenes for mechanistic insights which could lead to development of host-directed treatments as alternatives or adjuncts to pathogen-directed drug therapy.

Ultimately, he aims to identify and validate new drug targets using repurposed drugs and chemical activators/inhibitors, as well as by gene knockdown in human/mouse macrophages and gene-deficient murine models. Suraj uses diverse tools such as deepCAGE transcriptomics, metabolomics, systems biology, flow cytometry and confocal microscopy in his research, and serves as Platform Academic for CIDRI-Africa’s Basic Science platform. He is also assisting North-West University with set-up of a murine model of TB infection.

Although both incidence and mortality rates are falling worldwide, TB is the leading infectious cause of death. In South Africa, 438 000 people were estimated to have newly contracted TB in 2016; although 81% of new cases were successfully treated in the previous year, the success rate fell sharply for people who had multi-drug or rifampicin resistant TB, or extensively drug resistant TB2. Suraj’s work has the potential to translate into treatment methods which could reduce dependence on antimicrobials and thereby abate drug resistance.

View Dr Parihar’s Google Scholar profile

 

References:

1. Ernst, J. D. The immunological life cycle of tuberculosis. Nat. Rev. Immunol. 12, 581–591 (2012).

2. WHO. Global Tuberculosis Report 2017. WHO (2017). doi:WHO/HTM/TB/2017.23

 

 

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